Theoretical Evaluation of the Interactions between Metal-Phthalocyanines and Various Fullerenes as Delivery Systems

The photodynamic therapy (PDT) represents a non-invasive method with good results in the treatment of superficial tumors. PDT is based on combination two factors, namely, non-toxic photosensitizing molecule and light source; photosensitizer absorbs photon radiation, leading to series reactions that cause irreversible damage affected tissue. present paper investigates photosensitization properties nine substituted metal-phthalocyanines (the central metals being iron, nickel, zinc). In addition, interactions between aforementioned compounds four fullerenes are investigated by means molecular docking studies order verify their potential as delivery systems for phthalocyanines. Our outline mainly influenced type substituent lesser extent nature metal. binding energies towards suggest slight increased affinity fullerene C52 compared three nitrogen- phosphorus-doped C46N3P3 fullerenes.